Maltoflor

It is a dietary supplement containing the probiotic Saccharomyces boulardii, which promotes the balance of intestinal flora, carbohydrate, vitamins and minerals. The factors that threaten the well-being of the intestinal flora are manifold: unbalanced diet, temperature, viral and bacterial infections, taking antibiotics, the latter in fact alter the physiological balance of intestinal flora.

Saccharomyces boulardii is a yeast, therefore resists the acidic environment of the stomach and antibiotics. (1)

The ESPGHAN guidelines for the treatment of acute gastroenteritis in children(2) recognize the efficacy of Saccharomyces boulardii as an adjuvant for the treatment of diarrhea.

(1) Edwards-Ingram L., Gitsham P., Burton N., Warhurst G., Clarke I., Hoyle D., Oliver S. G., and Stateva L. (2007). Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cervisiae. Appl Environ Microbiol73, 2458-2467.
(2) European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. Alfredo Guarino et al. JPGN 46:S81–S122, 2008.

Maltoflor with Saccharomyces boulardii is a dietary supplement that promotes the balance of intestinal flora in the event of deterioration due to diarrhea of various origins (viral, associated with antibiotic therapy, infectious Clostridium difficile).

Clinical studies, in fact, show that S. boulardii can be used in case of:

  • acute gastroenteritis,(3)
  • diarrhea associated with antibiotic therapy,(4)
  • diarrhea of viral origin,(5)
  • Clostridium difficile-associated diarrhea in adults(6)

Maltoflor contains:

  • S. boulardii to support the balance of intestinal flora;
  • fructose and maltodextrin to glucose intake;
  • potassium to contribute to the normal functioning of the nervous system and normal muscle function;
  • magnesium for the electrolyte balance;
  • vitamins A, C and D3 to contribute to the normal functioning of the immune system;
  • vitamins B1, B2, B6 to contribute to energy metabolism.

Dietary supplements are not intended as a substitute for a varied diet, balanced and healthy lifestyle.

(3) TB Ozkan et al. Effect of Saccharomyces boulardii in Children with Acute Gastroenteritis and Its Relationship to the Immune Response. Journal of International Medical Research 2007 35: 201.
(4) Lewis SJ et al. The lack of therapeutic effect of Saccharomyces boulardii in the prevention of antibiotic-related diarrhoea in elderly patients. J Infect 1998;36:171-4.
(5) Kollaritsch H et al. Prevention of traveler’s diarrhea with Saccharomyces boulardii. Results of a placebo controlled double-blind study. Fortschr Med. 1993 Mar 30;111(9):152-6.
(6) Castagliuolo I et al. Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa. Infect Immun 1999;67:302-7.

Maltoflor is a dietary supplement containing the probiotic Saccharomyces boulardii, carbohydrates, vitamins and minerals.

Maltoflor does not contain gluten.

It has a pleasant taste that does not alter the taste of the drinks and facilitates fluid intake.

Dosage:

  • 1 sachet for day for infants
  • 2 sachets for day for children and adults

How to use: Dissolve the contents of one sachet in 150 ml of water, tea, chamomile or milk, at room temperature. It is recommended that the administration in the fasting state or at least 15 minutes before meals, in small sips to prevent gastric distension and the resulting gag reflex. During treatment with antibiotics Maltoflor can be administered simultaneously to these.

Packaging: 10 sachets of 15.5 g

Storage: Store at room temperature in a cool , dry place. Avoid exposure to sources of localized heat , direct sunlight and contact with water. The expiration date refers to the product properly stored. Any slight variation in color is not an indication of quality deterioration of the product. Do not dispose into the environment after use.

Warnings: Do not exceed the recommended daily dose. Do not mix the product with liquid too hot. If symptoms persist consult your doctor. Keep out of the reach of children under three years of age. Dietary supplements are not intended as a substitute for a varied diet, balanced and healthy lifestyle.

Ingredients: Maltodextrin, fructose, potassium phosphate, magnesium citrate, Saccharomyces boulardii MYA-796 (maltodextrin) tit. 20 billion/g; anti-caking agent: silicon dioxide, vitamin C (L-ascorbic acid), vitamin A acetate (retinyl acetate, sucrose, starch) tit. 9.75%, vitamin D3 (cholecalciferol, medium chain triglycerides, sucrose, modified starch) tit. 0:25 %, vitamin B6 hydrochloride (pyridoxine hydrochloride), vitamin B2 sodium 5-phosphate (sodium riboflavin 5-phosphate), vitamin B1 hydrochloride (thiamine hydrochloride).

In the production of Saccharomyces boulardii are used derivatives of the milk that are analytically absent in the finished product.

NUTRITION FACTS
 IngredientsFor 100 gFor 2 sachets% RDA for 2 sachets
Maltodextrin58,064 g18 g
Fructose36,129 g11,2 g
Potassium967,74 mg300 mg15
Saccharomyces boulardii15,48 mld4,8 mld
Magnesium290,3 mg90 mg24
Viatmin C64,52 mg20 mg25
Vitamin B6
6,45 mg2 mg142,8
Vitamin B2
5,16 mg1,6 mg114,2
Vitamin B1
4,51 mg1,4 mg127,3
Vitamin A
1570 µg488 µg61
Vitamin D3
24 µg7,5 µg150
Energy376,8 kcal116,8 kcal
1601,3 kJ496,4 kJ

S. boulardii reduces the duration of acute gastroenteritis in children and improves the immune response

A study published in the Journal of International Medical Research in 2007 confirmed the efficacy of Saccharomyces boulardii in the treatment of acute gastroenteritis and in improving in infants, probably, the immune response.

The study was conducted on children with acute diarrhea, aged between 6 months and 10 years, including the group 1 (n = 16) received 250 mg of Saccharomyces boulardii dissolved in 5 ml of water twice a day; while group 2 (n = 11) received placebo.

The results showed a significant reduction in the frequency of defecation on the 3rd and 4th day for children in group 1 (those who took the supplement of Saccharomyces boulardii).

In addition, the group that took the supplement with Saccharomyces boulardii showed an increase in plasma levels of immunoglobulin A.

SOURCE: Effect of Saccharomyces boulardii in Children with Acute Gastroenteritis and Its Relationship to the Immune Response TB Ozkan, E Sahin, G Erdemir and F Budak. Journal of International Medical Research 2007 35: 201.

RELATED STUDIES:

Saccharomyces boulardii in acute childhood diarrhoea: a randomized, placebo-controlled study.Villarruel G, Rubio DM, Lopez F, Cintioni J, Gurevech R, Romero G, Vandenplas Y. Acta Paediatr. 2007;96(4):538-41.

Effect of Saccharomyces boulardii in the Treatment of Acute Watery Diarrhea in Myanmar Children: A Randomized Controlled Study. Khin Htwe, Khin Saw Yee et al. Am. J. Trop. Med. Hyg., 78(2), 2008, pp. 214–216.

European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/European Society for Paediatric Infectious Diseases Evidence-based Guidelines for the Management of Acute Gastroenteritis in Children in Europe. Alfredo Guarino et al. JPGN 46:S81–S122, 2008.

 

S. boulardii in the prevention of antibiotic-associated diarrhea in children

A study published in Alimentary Pharmacology & Therapeutics in 2005 has shown that Saccharomyces boulardii reduces the risk of diarrhea associated with antibiotic therapy.

The randomized, double-blind, placebo-controlled study was conducted on 269 children, aged between 6 months and 14 years, suffering from ear infections and / or respiratory infections in these children, 132 have taken 250 mg of Saccharomyces boulardii twice daily for the duration of treatment with antibiotics, while 137 children receiving placebo.

The results showed that only 8% of children in the group Boulardii had diarrhea, while in the control group, the percentage rises to 23%.

 

SOURCE: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. M. KOTOWSKA, P. ALBRECHT & H. SZAJEWSKA. Aliment Pharmacol Ther 2005; 21: 583–590.

RELATED STUDIES:

Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea. A Systematic Review and Meta-analysis. Susanne Hempel, PhD et al. JAMA, 2012. Vol 307, No. 18